Recipient's immune system governs stem cell regeneration
A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance...
View ArticleISG15: A novel therapeutic target to slow breast cancer cell motility
Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes...
View ArticleResearchers indentify a cell-permeable peptide that inhibits hepatitis C
Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks viral replication, which can lead to liver...
View ArticleKeeping up with demand for red blood cells
(Medical Xpress) -- Two cellular proteins team up to provide a steady supply of red blood cells (RBCs), according to a study by Lizhao Wu, PhD, of the University of Medicine and Dentistry of New...
View ArticleResearchers find potential cancer roadblock
By identifying a key protein that tells certain breast cancer cells when and how to move, researchers at Michigan State University hope to better understand the process by which breast cancer spreads,...
View ArticleDiscovery may shed light on why some HIV-positive patients have more virus
(Medical Xpress)—Biologists at UC San Diego have unraveled the anti-viral mechanism of a human gene that may explain why some people infected with HIV have much higher amounts of virus in their...
View ArticleHCMV researchers utilize novel techniques to show preferential repair of the...
A new study about Human Cytomegalovirus (HCMV), a leading cause of birth defects, reveals how the virus co-opts cells' abilities to repair themselves. In the paper published on November 29 in the Open...
View ArticleCholesterol helps regulate key signaling proteins in the cell
Cholesterol plays a key role in regulating proteins involved in cell signaling and may be important to many other cell processes, an international team of researchers has found.
View ArticleThe new age of proteomics: An integrative vision of the cellular world
The enormous complexity of biological processes requires the use of highperformance technologies —also known as 'omics'—, that are capable of carrying out complete integrated analyses of the...
View ArticleImmune system foiled by a hairpin
The innate immune system detects invasive pathogens and activates defense mechanisms to eliminate them. Pathogens, however, employ a variety of tricks to block this process. A new study shows how the...
View ArticleScientists find key element of lupus, suggesting better drug targets
A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of...
View ArticleCervical cancer: First 3-D image of an HPV oncoprotein
(Medical Xpress)—For the first time, researchers from the Laboratoire biotechnologie et signalisation cellulaire at the Strasbourg-based Ecole supérieure de biotechnologie (CNRS/Université de...
View ArticleResearchers find that two antagonistic proteins help keep leukemia at bay,...
Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to...
View ArticleCancer-promoting protein found to also suppress cell growth
Some cellular proteins have multiple, and occasionally opposing, functions. Professor Adrian Krainer [link: Faculty profile] and colleagues at Cold Spring Harbor Laboratory demonstrate in a paper...
View ArticleTeam discovers how cells distinguish friend from foe
(Medical Xpress)—Researchers at UC Davis have shown how the innate immune system distinguishes between dangerous pathogens and friendly microbes. Like burglars entering a house, hostile bacteria give...
View ArticleStudy identifies genetic suspects in sporadic Lou Gehrig's disease
Researchers at the Stanford University School of Medicine have identified mutations in several new genes that might be associated with the development of spontaneously occurring cases of the...
View ArticleResearchers investigate 59 tumor cell lines
In what is the biggest study of its kind to date, researchers from Technische Universität München (TUM) have identified over 10,000 different proteins in cancer cells. "Nearly all anti-tumor drugs are...
View ArticleHow untying knots promotes cancer
Researchers have long known that high levels of a specific protein in human cells are linked to tumor growth – but no one has fully understood how.
View ArticleResearch discoveries uncover secrets of immune system
A series of discoveries made by scientists at the University of Dundee is helping to uncover the secrets of how chronic inflammatory and autoimmune diseases such as Lupus and rheumatoid arthritis are...
View ArticleNew approaches for Ebola virus therapeutics
Researchers from the University of Liverpool, in collaboration with Public Health England, have investigated new ways to identify drugs that could be used to treat Ebola virus infection.
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